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The real problem of how to distinguish whether the lesion is benign or malignant remains, as an early diagnosis of melanoma can be crucial for the prognosis

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It is accepted that cocaine can inhibit the re-uptake of norepinephrine by blocking transport in the presynaptic sympathetic neuron, which results in an abundance of norepinephrine in the synaptic cleft and the consequent propagation of sympathetic discharge [34]
