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3.3 Weight management and body composition optimization: foundational effect for reproductive benefit Across the diverse landscape of evidence involving various comparators and time windows, weight loss and improvements in body composition emerge as the most consistent and clinically interpretable benefit findings of GLP-1RAs in PCOS, particularly within obesity- and IR-dominant phenotypes

A key double-blind, placebo-controlled phase II study conducted over 72 weeks recruited 320 individuals with histologically confirmed NASH and liver fibrosis classified as stage F1 to F3

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Dehydration forces kidneys to work harder to filter waste, raising the risk of acute kidney injury, kidney stones, and chronic kidney disease