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John Mann, co-director of the Center for the Prevention and Treatment of Depression at Columbia University, said in an interview the study marked a significant advance over earlier work that suggested GLP-1s can improve depression: "Whats been missing is randomized clinical control studies

This facilitates meaningful weight loss and supports heart function and metabolic balance

Switching to an oral pill may appeal to those who dislike injections or want a simpler dosing routine, while a lower injectable dose may offer a cheaper option that may also result in less adverse events