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McGuire DK, Busui RP, Deanfield J, Inzucchi SE, Mann JFE, Marx N, Mulvagh SL, Poulter N, Engelmann MDM, Hovingh GK, Ripa MS, Gislum M, Brown-Frandsen K, Buse JB

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ligand binding makes the cleavage site accessible, leading to shedding of the Notch ectodomain as the first step of signal transduction [[3][3], [4][4]]

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