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Early Alzheimer-type lesions in cognitively normal subjects
Thus GLP-1 was shown to regulate a number of diverse functions: reduction in digestive enzyme secretion, slowing of gastric motility, increases in heart rate and blood flow, increased bone remodeling, and suppression of appetite (via hypothalamic and brainstem nuclei)

The Positive and Negative Effects of GLP-1 Drugs Are Closely Intertwined Warren Yacawych, a neuroscientist at the University of Michigan, and his team tried to disentangle GLP-1 drugs desired effects (reduced food intake and weight loss) from their unwanted accompaniments (often nausea and vomiting)

Chen J, Lin A, Luo P