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236 Dysregulation of various miRNAs within different fluids (e.g., blood, saliva, and urine) is associated with obesity and IR development, including -cell dysfunction, glucose and lipid homeostasis, and chronic inflammation

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6.5.3.2 Safety and tolerability Across the PIONEER program, the safety and tolerability of oral semaglutide were generally consistent with the known profile of GLP-1RAs