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Our findings revealed that Y1-R signaling directly stimulated glucose uptake in muscle tissue via a pathway that is independent of insulin-stimulation

Many trials lack stratification based on ejection fraction, hindering the ability to determine the differential effects of GLP-1RAs in various heart failure subtypes

The combined effect on gastric emptying could increase gastrointestinal side effects, and there is no clinical data on the safety of combining GLP-1 Complete specifically with semaglutide or tirzepatide