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Among patients also receiving metformin immediate-release, the median daily insulin (pre-mixed, intermediate or long acting) dose at baseline was 40 units in the sitagliptin-treated patients and 42 units in the placebo-treated patients
Medical therapy is ineffective in treating the underlying cause although can treat consequences from heart failure
The latter, however, has yet to be FDA-approved for weight loss in folks under age 18
So, while GLP-1s might be helpful, the risk-benefit trade off for these groups might not be worth it
