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But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators

Exceptional results with GLP-1s have led many Americans with obesity (BMI 30) and even those without to seek these medications as a treatment option.

Our bodies regulate food intake and energy expenditure via cells in the intestinal wall that sense certain nutrients, then release peptides which activate neurons