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Hypoglycemia awareness Tight glycemic control is a risk factor for impaired glucose counter-regulation and hypoglycemia unawareness lower levels of HbA1c result in a resetting of thresholds for the counter-regulatory and symptomatic responses to hypoglycemia at lower glucose concentrations

These findings highlight variations in the signals that stimulate GLP-1 release from GLP-1 EECs and NTS neurons expressing preproglucagon

(44) reported that both GIPR agonist (GIPRA) and dual GIP/GLP-1 receptor agonist similarly improved glucose tolerance in GLP-1R knockout mice, but not in dual incretin receptor knockout mice

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