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Notably, all patients had previously been treated with pentosan polysulfate, which is currently the only FDA approved treatment for interstitial cystitis, and had not responded

If your primary concern is fatigue and low energy , B12 makes more sense

Clinical Trial Data: How Common Are Semaglutide-Related Headaches

In Australia, semaglutide is PBS-listed for type 2 diabetes but not currently for weight loss alone
