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For type 2 diabetes patients specifically, TRANSCEND-T2D-1's results meaningful HbA1c reduction alongside 16.8% weight loss, with better tolerability than the obesity trials make retatrutide a potentially attractive option if approved for that indication

Additionally, as of January 2025, Ozempic is now approved for use in patients with type 2 diabetes who also have chronic kidney disease

Once-weekly glucagon-like peptide-1 receptor agonists vs dipeptidyl peptidase-4 inhibitors: cardiovascular effects in people with diabetes and cardiovascular disease

[DOI] [PubMed] [Google Scholar] 49.Zhang M.Q., Lin C., Cai X.L., Jiao R.Y., Bai S.Z., Li Z.L., Hu S.Y., Lyu F., Yang W.J., Ji L.N