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Appetite Changes Most people experience: Reduced hunger Feeling full sooner Less interest in snacking These changes often happen within days, even before weight loss begins
Discontinuation rates undermined the value argument Cost alone might not have tipped the scales
Source: Pharmaceutical Industry News, published 25 April 2026
The authors suggested that GLP-1 RAs and SGLT-2is may be particularly effective in advanced metabolic dysfunction, whereas metformin may remain preferable for less complex cases [172]
