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The distinction between semaglutide and tirzepatide did not matter for coverage purposes

Conversely, when this framework is extended to reproductive endpointswhich are subject to greater definitional heterogeneity and effect modificationthe appearance of long-tailed distributions suggests that the quantified probability of efficacy may not demonstrably exceed that of metformin

Adding the 9mg arm suggests the sponsor believes the 8mg to 12mg range contains the optimal therapeutic dose and wants more granular data to identify it precisely

The glucagon receptor component introduces a theoretical concern about bone density, as glucagon signalling has been associated with increased bone resorption in some preclinical models