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If tirzepatide monotherapy does not produce desired results after 1216 weeks at therapeutic dosing, or if tolerance develops, your physician may consider adding phentermine or exploring alternative approaches

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Semaglutide reduced the risk of death from heart disease, nonfatal heart attack, and nonfatal stroke by 20 percent in people with established heart disease who were overweight or obese but who didnt have diabetes

This enables the use of low dose aspirin as a selective antiplatelet drug (Figure 2) At higher doses, aspirin inhibits both isoforms of COX (Figure 2)