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To minimize treatment interruptions due to adverse reactions, subsequent Phase III clinical trials may adopt a more gradual dose-escalation strategy to reduce the incidence and severity of gastrointestinal discomfort and other adverse events, thereby enhancing patient tolerance and adherence to the medication

Although we adjusted for a wide range of baseline clinical and demographic characteristics, the possibility of residual confounding by unmeasured factors, such as lifestyle, frailty, or socioeconomic status, remains

The move was meant to reduce spending on weight loss drugs for the insurer, which recently laid off 110 people, or 2 percent of its workforce, as its finances deteriorated

Callaghan, B., Furness, J