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To maintain a healthy eating regimen while on Tirzepatide, it is recommended that you reduce your daily calorie consumption by 500-1000 calories

That is an important difference from semaglutide, where the risk clearly rises with the dose

On average, tirzepatide has been shown in research to lead to a greater amount of weight loss : People with obesity in clinical trials for tirzepatide lost, on average, 20% of their body weight at week 72 (and about 7 inches off their waistlines), compared with about 14% of their body weight (and about 5 inches off their waistlines) with semaglutide

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