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Several confounding factors may explain joint symptoms in patients taking tirzepatide
This dual mechanism is why tirzepatide is widely considered a breakthrough in the GLP-1 drug class
Weight-bearing loads from body weight contribute to bone maintenance, and losing significant weight removes some of that mechanical stimulus
Monitoring for new autoimmune manifestations Although rare, the possibility that GLP-1/GIP receptor agonism could trigger new autoimmune manifestations in susceptible individuals has been raised by case reports
