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gip vs glp 1 receptor agonist The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) tirzepatide: a novel cardiometabolic therapeutic prospect | Cardiovascular Diabetology Dual and Triple Gut Peptide
Description
Background With the prevalence of obesity rising in the US, medical management is of increasing importance

For humans, the model-predicted median clearance (CL) and volume of distribution (Vss) of semaglutide were 0.0397 L/h and 6.23 L, respectively

Although dedicated trials of GLP-1RAs in AITD are lacking, preliminary reports suggest potential impacton thyroid volume, thyroid function, and autoimmune activity

Data are presented as medians (interquartile ranges) or frequencies (%), and Wilcoxon signed-rank tests and Mann-Whitney U tests were used for paired and nonpaired group comparisons, respectively