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FDA-approved GLP-1 drugs are injections or oral medications that are designed to mimic the effects of GLP-1, a naturally occurring hormone that regulates blood sugar and appetite in the body

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For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose

In short, liraglutide, GLP-1 receptor agonist, has a direct effect on atherosclerosis lesion formation via promoting pro-resolving M2 macrophages phenotype