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About 30% of patients experience abdominal issues such as nausea, diarrhea, or constipation

SELECT Trial Cardiovascular Disease 20% reduction in the risk of cardiovascular events 37% risk reduction in a broader set of secondary outcomes (including cardiovascular death and stroke) FLOW Trial Chronic Kidney Disease: Novo Nordisks clinical trial , which enrolled 3,533 people with type 2 diabetes and CKD, was ended early as a result of clear efficacy

PLoS One 2017;12:e0173515

Patients should prioritize protein intake to preserve lean body mass during weight loss, aiming for 1.0-1.5 grams per kilogram of ideal body weight daily (lower for those with chronic kidney disease), distributed across meals