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Gaps in the literature and research needs Under-Explored Adverse Effects Long-term metabolic effects: Accumulating evidence suggests potential correlations between chronic SSRI exposure and metabolic disturbances, including weight gain, insulin resistance, and dyslipidemia, though establishing definitive causality remains challenging given the confounding effects of depression itself on metabolic parameters

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Most reports involved men aged 4060 with T2D being the main indication of use (43.9%)

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