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Semaglutide for Obesity, NEJM 2025 Rodriguez et al

While gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) affect many patients initially, severe or persistent symptoms may necessitate dose adjustment, temporary dose reduction, or consideration of alternative therapies

More serious potential side effects include: Gallbladder issues Pancreatitis Potential risk for heightened thyroid c-cell tumors Kidney injury Tirzepatide vs Semaglutide cost for weight loss Securing insurance coverage for weight loss medications can be challenging, so the cost will often come completely out-of-pocket

Plus, many men see hormonal changes and maintain testicular size right from the get-go