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Activation of this pathway results in protein synthesis, hypertrophy and inhibition of the key ubiquitin ligase atrogin-1 by inactivating Foxo factors[82], IGF-IR also phosphorylates Shc, which subsequently activates the RAS/Raf/MEK pathway leading to cell proliferation and mitogenesis[2]

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doi: 10.3389/fmicb.2023.1163662 Received 11 February 2023 Accepted 26 April 2023 Published 24 May 2023 Volume 14 - 2023 Edited by Giuseppe Spano, University of Foggia, Italy Reviewed by Victor Sebastian Blancato, CONICET Instituto de Biologa Molecular y Celular de Rosario (IBR), Argentina