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Description

Tailoring drug administration to individual seizure susceptibility patterns exemplifies how chronotherapy can optimize epilepsy management: differential dosing allows for delivering higher treatment levels at the times of greatest vulnerability, while minimizing side effects during periods of lower risk (Thome-Souza et al., 2016)

Melatonin is a widely spread indoleamine derivative (chemically identified as N-acetyl-5-methoxytryptamine) hormone largely synthesized by the pineal gland and can also be found in small quantities in organs such as the retina, lens, gut, bone marrow, skin, and other solid organs with multifunctional facets (Xu et al., 2019), the elevation of antioxidant properties, restoration of antioxidants like glutathione (Paul et al., 2018), reduction of the amyloid- (A) and anti-inflammatory action (Lee et al., 2018a)

Purpose of review Sarcoidosis is a chronic multisystemic inflammatory disease of unknown aetiology with a wide range of highly variable clinical manifestations and unpredictable disease course