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This article examines the side effect profile of B12 therapy in older adults, covering common reactions such as injection site discomfort and gastrointestinal symptoms, rare serious adverse events requiring urgent medical attention, important drug interactions with medications like proton pump inhibitors and metformin, and evidence-based dosing guidance aligned with NICE and BNF recommendations for safe, effective B12 replacement in this vulnerable population

and discovered in the ruins of the ancient Egyptian city of Akhetaten, are full of accounts of magnificent gifts offered by one great king to another

Its dual-action mechanism targets both GLP-1 and GIP (gastric inhibitory peptide) receptors, helping to improve insulin sensitivity, reduce hunger, and promote satiety

doi: 10.1038/nbt.2931 84 RitchieM