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That chronic derangements and organic pathologies are implicated is also suggested by the fact that neuronal atrophy has been observed in depressed patients and in animal behavior models for depression

A higher risk of developing PD has been linked to variants in a number of PARK-designated (SNCA, UCHL1, LRRK2, PARK 16, GAK) and a few additional genes (MAPT, GBA, NAT2, INOS2A, GAK, HLA-DRA, and APOE) (Postuma et al., 2015)

Sequentially, this interaction initiates translocation of the cytoplasmic subunits to the membrane and the formation of the active complex