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Although there is an active search for effective treatments of HF, up to 50% of diagnosed patients have died in the past 30 years, indicating that the pathogenesis of this disease has not yet been fully elucidated (90)

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Ke Y., Li D., Zhao M., Liu C., Liu J., Zeng A., Shi X., Cheng S., Pan B., Zheng L., et al

Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived little mice

These findings indicate that the most affected component of OXPHOS in ASD patients is complex I, but abnormalities in the activity of other complexes, such as complexes III, IV, and V, can also be found