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Off J Am College Gastroenterol
[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Heidler T., Hartwig K., Daniel H., Wenzel U
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The increased lipid content in the liver could be attributed to the up-regulation of the mRNA levels of SREBP , PPAR , fatty acid synthase ( FAS ) and ACCa and the increased activities of lipogenic enzymes (such as FAS, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme) and to the down-regulation of the mRNA levels of the lipolytic gene CPT1A
