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Importantly, peptide analogs with stapling moieties present at the hydrophobic interface (1914, 1919, 1921, 2015, 2017) had limited improvement or even loss of activity compared to LD2, suggesting that substitution of these interfacial residues disrupted key hydrophobic interactions (Table 1)
Gen Comp Endocrinol (2009) 164:4050
However, oral zinc may cause gastrointestinal discomfort, nausea, or poor absorptionespecially during illness
Unlike traditional medications that often have broader effects, peptides can target specific receptors and pathways, leading to more precise and potentially fewer side effects
