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Active ingredients must pass through the skins outermost barrier, which typically allows only very small molecules to penetrate

synthesis and its subsequent dismutation to H 2 O 2 in the apoplast, is a common response to pathogens, elicitors, wounding, heat, ultra-violet light, and ozone (Orozco-Cardenas et al., 2001

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Genistein modulates neuroblastoma cell proliferation and differentiation through induction of apoptosis and regulation of tyrosine kinase activity and N-myc expression