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P53 directly increases GH production, endocrine GH promotes the expression of ATM through JAK2-activated TRIM29, and next regulates HR pathway to repair DNA damage (Sho et al., 2011)

However, in scurvy, vitamin C is retained by the brain for neuronal function, and eventual death from the disease is more likely due to lack of vitamin C for collagen synthesis (44)

Ozone infiltration for osteonecrosis of the jaw therapy: a case series