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Taking it with meals has shown to decrease its absorption from the gut. Eating certain foods too close to your daily dosage can interfere with how the medication works, including: Soy-based foods or flours, like edamame, tofu, or miso Cottonseed meal Grapefruit or grapefruit juice Walnuts High-calcium foods, like milk, yogurt, or cheese High-fiber foods, like broccoli, cabbage, or kale Fatty, fried, or sugary foods can also slow your metabolism and make it harder to absorb medication

Leuk Lymphoma 53:18671875 Jundt J, Browne B, Fiocco G, Steele A, Mock D (1993) A comparison of low dose methotrexate bioavailability: oral solution, oral tablet, subcutaneous and intramuscular dosing