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The trial demonstrated that the reduction of autophagy through CQ/HCQ alongside CG is feasible and well-accepted at lower doses, with exosomal LC3B levels analyzed as a measure of autophagy control [344]

However, the clinical translatability of these in vitro findings remain equivocal owing to the absence of corroborative human tissue or cohort data

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Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis