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Description
Among different classes, Phi and Tau class GSTs are plant-specific and predominantly present, whereas the smaller Theta and Zeta classes, having restricted xenobiotic activity, are also found in animals
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thus, the ratio of GSH to GSSG is used as an indicator of oxidative stress
The Cystine/Glutamate antiporter, SLC7A11/xCT, mediates the uptake of extracellular cystine, which is reduced to cysteine, the precursor for glutathione synthesis, protecting cells from oxidative stress [6]
