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doi:10.1111/jdv.14721 109
G., Seth, P., Everett, P., Clish, C
In summary, neuroprotective capacity is a major differentiator: natural compounds engage pathways (antioxidant responses, antiapoptosis, protein homeostasis, etc.) that maintain neuron health, whereas levodopa largely bypasses these diseasemodifying mechanisms (Figure 5)
Supporting a role for these microglia changes in disease pathology is the fact that a remarkable overlap exists between the sites of cellular pathology and the brain regions with altered structure and function in neuroimaging studies of bipolar illness (164)
