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Population Limitations: As noted previously, the trials did not include elderly individuals, pregnant women, children, or those with certain medical conditions

The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

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Coenzyme A is needed for acetylation, an important part of a number of physiological chemical reactions, most notably in the metabolism of energy [28]