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McKee KK, Palyha OC, Feighner SD, et al
, & Bertoli, S
SAMe depletion decreases the methylation capacity of the cell, indicated by the SAMe/SAH ratio, producing a reduction of CpG islands methylation and global DNA hypomethylation that leads to aberrant gene expression and compromises genomic stability [63]
PLoS ONE 9(8) , e104637, (2014) SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this mode
