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Across these contexts, N1-type neutrophils are consistently defined by a proinflammatory program that amplifies inflammatory cascades, disrupts tissue homeostasis, and drives multi-organ dysfunction

10.1080/09513590701557416 16 BogusiewiczM.Stryjecka-ZimmerM.RechbergerT

J Clin Invest 1965

The EFFIGACT study, a 6-month randomized controlled trial that enrolled and randomized 156 patients, showed that ACT was statistically superior to both the recommended pharmacological treatment (RPT: pregabalin + duloxetine) and the waiting list immediately after treatment, and improvements were maintained after 6 months [36, 37]
