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In this context, its important to highlight the emerging role of membrane contact sites (MCS) in lipid transfer

While our efforts to define the endogenous ligand for NHR-49 were unsuccessful, mutating the ligand-binding pocket might allow us to determine the role of ligand binding in the transcriptional activity of NHR-49

If a drug is taken into the gastrointestinal tract (GI tract), where it enters the hepatic portal system through the portal vein, it becomes well-metabolized and is said to show the first pass effect

This metabolite is not found in human plasma or liver but is present in ocular tissues, suggesting specific metabolic pathways in the eye [22,23]