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Martin Schlott empfiehlt, sich tagsber im Tageslicht zu bewegen, denn in der Sonne werde Serotonin gebildet und das sei die Vorstufe fr Melatonin

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The overall response rate (ORR) for CM patients to ipilimumab, nivolumab, pembrolizumab and atezolizumab is 12%, 40%, 33% and 30% respectively (167169), while the combined treatment of ipilimumab with nivolumab significantly improves the ORR to 61% with median progression-free survival (PFS) of 11.5 months (170, 171)

If no pre-existing neuropathy is detected, clinicians should deliver education focused on early symptom detection and encourage prompt reporting of paresthesia, numbness, or motor changes