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Description
Minimal Systemic Effects: Works primarily at the application site with limited whole-body exposure

Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression
They allege that drug manufacturers didnt warn them of potential unlisted side effects

TP53 , PTEN , and ARID1A mutations are inactivated, while PIK3CA , KRAS , and PPP2R1A are activated