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In addition, encouraging anti-tumor activity has been observed with xentuzumab, whereby two out of 48 (4%) patients in the Asian study had a partial response and a further 15 (31%) patients had stable disease [78]

Administration of the antioxidant N-acetylcysteine (NAC) prevented the anti-cancer effects of vitamin C, supporting that increased ROS were responsible for this effect

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2 Pathogenesis of pulmonary fibrosis Tissue repair following injury is an inherent biological mechanism that restores tissue integrity through the organized replacement of damaged or deceased cells (Figure 1: the initial sustained injury phase, the inflammatory cell migration phase, the fibroblast migration/proliferation/activation phase and finally, the excessive deposition of ECM and fibrosis phase