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Rouhier et al., 2002, 2006

Nrf2 -null mice suffer from acute hepatotoxicity after acetaminophen exposure ( Nrf2 -null mice ( Nrf2 -null mice are more susceptible to cigarette smoke-induced emphysema (Rangasamy et al., 2004), bleomycin-induced pulmonary fibrosis ( Nrf2 gene has been linked to the reduced expression of Nrf2 and subsequent lung damage caused by hyperoxia ( NRF2 gene also harbors SNPs in the promoter region (Yamamoto et al., 2004), which have been linked to the risk of acute lung injury (Marzec et al., 2007)

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This divergent outcome suggests that the involvement of peroxidases in enzymatic browning is species-dependent and dictated by the differential regulation of specific isoforms or members under contrasting physiological scenarios