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57 Mice with conditional deletion of IGF-1 in chondrocytes have reduced bone accretion during postnatal bone growth

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and elevated 4-HNE levels found in both cartilage and synovial fluid of surgically induced canine OA models, where direct intra-articular injection of 4-HNE could replicate the cartilage destruction phenotype, accompanied by significant upregulation of MMP13, ADAMTS5, and cyclooxygenase-2 (COX2) expression (Shi et al., 2014)

In this review, we discuss how peptide-based tumor immunotherapy transforms PCa from a cold to a hot state by modulating the TME of PCa and inducing ICD in PCa cells, thereby enhancing the response of PCa to immunotherapy