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An imbalance between pro-oxidants and antioxidants is also evident in ME/CFS: pro-oxidants such as peroxides and superoxides are elevated (correlating with symptom severity), nitrosative stress is increased (with activation of NF-B pathway, also observed in Long-COVID patients) [11], and antioxidants levelsparticularly vitamin Eare reduced [7]

However, it is believed that high-fat dairy products may have a negative influence on UFs due to their association with hormonal imbalances and inflammation [79]

Stimuli such as NaCl, H2O2, UV radiation and anisomycin can regulate PFKFB3 transcription by binding to the serum response element in the PFKFB3 promoter via serum response factor (30)

plantarum 299v probiotic strain improved the antioxidant activity of fermented mushrooms to a level comparable of that in fresh mushrooms (JaboskaRy, Skrzypczak, et al., 2019b)