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Phosphatidylcholine synthesis by the phosphatidylethanolamine N -methyltransferase (PEMT) pathway is required for VLDL assembly and secretion from the liver (7, 8)

Woodward AJ, Wallen MP, Ryan J, Ward LC, Coombes JS, Macdonald GA

AIDS 2002;16:7583

This is because immature hiPSC-CMs have a lower expression of connexin 43 than AdCMs, and connexin 43 is distributed around the cells, whereas AdCMs have connexin 43 localized in the intercalated disk (Gilbert, 2021)
