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Sustained pro-inflammatory cytokine production In progressive MS there is increased microglia and macrophages reactivity into a pro-inflammatory phenotype, which may contribute to neurodegeneration via a number of potential mechanisms

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Toxicol Lett 47(2):191196 Adam V, Petrlova J, Wang J, Eckschlager T, Trnkova L, Kizek R (2010) Zeptomole electrochemical detection of metallothioneins
