nac glutathione pathway N-Acetylcysteine and Its Immunomodulatory Properties in Humans and Domesticated Animals Effect of N-Acetylcysteine on Sleep:

doi: 10.1002/uog.21893

Strikingly, substitution of a Cys for Sec lowers the enzymatic activity of GPx-1 by orders of magnitude (309), leading to the suggestion that a different mechanism involving a second resolving Cys is essential for the enzymatic activity of normally occurring nonselenium ( i.e ., Cys-containing) forms of GPxs, such as the GPxs in yeast strains that lack a Sec incorporation mechanism (359)

Caveats: scopolamine-induced impairment is a specific pharmacological model that doesnt capture the complexity of human cognitive disorders

Insulin-like growth factor-I response to a single bolus of growth hormone is increased in obesity