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Additionally, cytokine-targeting therapies, including tocilizumab (an anti-IL-6 receptor inhibitor) and anakinra (an anti-IL-1 receptor antagonist), have been shown to be effective in treating immune-mediated epileptic syndromes, such as new-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES) [358, 359]

Recombinant human insulin-like growth factor-I enhances whole body protein anabolism and significantly diminishes the protein catabolic effects of prednisone in humans without a diabetogenic effect

[DOI] [Google Scholar] 26.Nicolaides K., Rizzo G., Hecher K., Ximenes R

The success of this approach in modulating both energy metabolism and epigenetic regulation suggests that other metabolic nodes may offer similar opportunities for dual-pathway intervention